OKrill and Liver Health
The liver is capable of doing many important functions including filtering our blood, synthesizing proteins, producing hormones and help in digestion. It processes incoming nutrients, stores them or prepares them for transport to other organs. It is also responsible for removing hazardous toxins, alcohol, medications, fatty foods, and debris from the circulation.
OKrill’s essential ingredients omega-3, choline and phospholipids are ideally positioned to promote liver health and ensure an optimal functioning liver. Due to its distinctive composition of nutrients and natural balance of minerals, OKrill is the perfect supplement for liver health.
Krill Oil and Non Alcoholic Fatty Liver Disease (NAFLD)
A deposit of fat in the liver is the hallmark of liver disease, also known as Non Alcoholic Fatty Liver Disease (NAFLD), a dangerous disorder that is estimated to affect 25% of adults globally. It frequently goes unnoticed until it is too late. It is often seen in combination with diabetes, obesity, dyslipidemia, metabolic syndrome and cardiovascular disease. The essential nutrients of Krill Oil phospholipids, Omega-3 fatty acids and choline, are therapeutically effective to maintain good liver health.
As per study by Kathy Musa Veloso et al, Omega-3 LC-PUFAs are useful in dietary management of patients with NAFLD. The research merged the results of 18 studies that demonstrated beneficial effects on metabolic risk factors, liver enzymes, liver lipid content, and liver damage. The authors concluded that omega-3 fatty acids are an important NAFLD (fatty liver) treatment option. The article was published by Oxford University Press on behalf of the International Life Sciences Institute (ILSI).
Suggested Reading: Liver Health Krill Oil
Krill Oil Choline and European Food Safety Authority (EFSA)
Two health claims for choline (One of the important component of Krill Oil) linked to liver health have been accepted by the European Food Safety Authority (EFSA). EFSA is one of the strictest regulatory agencies in the world, with the justification that there is scientific evidence linking choline consumption to healthy liver function. The health claims are:
“Choline contributes to normal liver function”
“Choline contributes to normal fat metabolism”
Suggested Reading: Krill Oil & Liver Scientific Opinion On The Substantiation of Health Claims Related to choline and Contribution to
Krill Oil and Antisteatotic Effects in Liver
The study by Gabriella Sistilli et al, concluded that in addition to Omega-3 PLs, other constituents of krill oil including alkaloids, may contribute to its strong antisteatotic effects in the liver. The potent antisteatotic effects of krill oil, which have been observed in prevention and reversal of hepatic steatosis, were associated with improved insulin sensitivity in the liver and at the systemic level.
Suggested Reading: Krill Oil & Liver
Krill Oil and Liver Injury
Krill Oil is full of nutrients like n-3 polyunsaturated fatty acids (n-3 PUFAs), phospholipids, astaxanthin, and vitamins. These nutrients have anti-inflammatory, antioxidant, lipid metabolism regulating, and low-cholesterol effects. The study by Peiyu Guo et al. in the Journal of Nutritional Biochemistry, have shown that krill oil could help in healing liver damage, caused by eating too much iron or too much fat. The results showed that taking krill oil supplements could be a new way to treat liver damage.
Krill Oil’s Effects on Inflammation
As per the study done by Evelin Gart et al, the long-term Krill oil treatment (28 w), the liver and white adipose tissue (WAT) both had higher levels of anti-inflammatory PUFAs and oxylipins after receiving long-term Krill oil administration. They were complemented by favorable effects on overall metabolism and tissue-level inflammation. Krill oil’s acceleration of adipogenesis permits secure fat storage and reduces inflammation.
Suggested Reading: Krill Oil & Liver Health
Preventive and Therapeutic Effects of Krill Oil on Obesity
The study by Seung Min Hwang et al concluded that the Krill oil demonstrated liver antioxidant activity as well as glucose reducing effects. It also helped in improving hepatic steatosis, pancreatic endocrine/exocrine dysfunction, adipose tissue hypertrophy, and renal steatosis.
The study suggest that Krill oil may be promising for inhibiting obesity and metabolic syndromes.
Suggested Reading: Krill Oil & Liver.
Krill Oil Prevents Body Weight Increase
As per the research conducted by Alessandra Ferramosca et al, the Krill Oil supplementation prevented an increase in body weight, as well as oxidative damage of lipids and proteins, which is often found in high-fat fed animals. Krill oil supplementation prevented an increase in body weight, as well as oxidative damage of lipids and proteins, which is often found in high-fat fed animals.
Suggested Reading: Krill Oil & Liver
Krill Oil Alleviates Oxidative Stress and Iron Accumulation In The Liver
The study by Helal MG et al reveals that Krill oil effectively improved the microscopic features of liver and spleen. Moreover, it decreased the increased levels of serum transaminases, ALP, LDH, iron, and ferritin and increased albumin serum level as well. In addition, it restored the balance between oxidants and antioxidants in the hepatic and splenic tissues.
Scientific Evidence:
1. Kathy Musa-Veloso and others, Systematic review and meta-analysis of controlled intervention studies on the effectiveness of long-chain omega-3 fatty acids in patients with nonalcoholic fatty liver disease, Nutrition Reviews, Volume 76, Issue 8, August 2018, Pages 581–602,
https://doi.org/10.1093/nutrit/nuy022
https://academic.oup.com/nutritionreviews/article/76/8/581/5039045?login=true
2. Scientific Opinion on the substantiation of health claims related to choline and contribution to normal lipid metabolism (ID 3186), maintenance of normal liver function (ID 1501), contribution to normal homocysteine metabolism (ID 3090), maintenance of normal neurological function (ID 1502), contribution to normal cognitive function (ID 1502), and brain and neurological development (ID 1503) pursuant to Article 13(1) of Regulation (EC) No 1924/2006 © 2011 European Food Safety Authority
https://doi.org/10.2903/j.efsa.2011.2056
https://efsa.onlinelibrary.wiley.com/doi/epdf/10.2903/j.efsa.2011.2056
3 Sistilli G, Kalendova V, Cajka T, Irodenko I, Bardova K, Oseeva M, Zacek P, Kroupova P, Horakova O, Lackner K, Gastaldelli A, Kuda O, Kopecky J, Rossmeisl M. Krill Oil Supplementation Reduces Exacerbated Hepatic Steatosis Induced by Thermoneutral Housing in Mice with Diet-Induced Obesity. Nutrients. 2021 Jan 29;13(2):437. doi: 10.3390/nu13020437. PMID: 33572810; PMCID: PMC7912192.
4. Peiyu Guo, Meilan Xue, Xiangyun Teng, Yanhui Wang, Rong Ren, Jianmin Han, Huaqi Zhang, Yingjie Tian, Hui Liang, Antarctic krill oil ameliorates liver injury in rats exposed to alcohol by regulating bile acids metabolism and gut microbiota, The Journal of Nutritional Biochemistry, Volume 107, 2022, 109061, ISSN 0955-2863,
https://doi.org/10.1016/j.jnutbio.2022.109061.
https://www.sciencedirect.com/science/article/abs/pii/S0955286322001322
5. Gart E, Salic K, Morrison MC, Caspers M, van Duyvenvoorde W, Heijnk M, Giera M, Bobeldijk-Pastorova I, Keijer J, Storsve AB, Hals PA, Kleemann R. Krill Oil Treatment Increases Distinct PUFAs and Oxylipins in Adipose Tissue and Liver and Attenuates Obesity-Associated Inflammation via Direct and Indirect Mechanisms. Nutrients. 2021 Aug 18;13(8):2836. doi: 10.3390/nu13082836. PMID: 34444996; PMCID: PMC8401900.
6.Hwang, S.-M.; Kim, Y.U.; Kim, J.-K.; Chun, Y.-S.; Kwon, Y.-S.; Ku, S.-K.; Song, C.-H. Preventive and Therapeutic Effects of Krill Oil on Obesity and Obesity-Induced Metabolic Syndromes in High-Fat Diet-Fed Mice. Mar. Drugs 2022, 20, 483.
https://doi.org/10.3390/md20080483
https://www.mdpi.com/1660-3397/20/8/483
https://pubs.rsc.org/en/content/articlelanding/2022/fo/d1fo04136c
7.Ferramosca A, Conte A, Burri L, Berge K, De Nuccio F, Giudetti AM, et al. (2012) A Krill Oil Supplemented Diet Suppresses Hepatic Steatosis in High-Fat Fed Rats. PLoS ONE 7(6): e38797.
https://doi.org/10.1371/journal.pone.0038797
https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0038797
8.Helal MG, El-Kashef DH. Krill oil alleviates oxidative stress, iron accumulation and fibrosis in the liver and spleen of iron-overload rats. Environmental Science and Pollution Research International. 2020 Feb;27(4):3950-3961. DOI: 10.1007/s11356-019-06983-1. PMID: 31823254.
https://europepmc.org/article/med/31823254
https://www.rejuvenation-science.com/research-news/krill-oil/n-krill-oil-organ-fat
*OKrill is made from 100% original, pure krill oil, extracted from the Krill found in the pristine waters of Antarctica.
