OKrill and Heart Health
According to World Health Organization, cardiovascular diseases (CVD) are the leading cause of death globally, taking an estimated 17.9 million lives each year. It is important to take good care of heart, as it functions like a powerhouse for the healthy body.
OKrill, a supplement made from the pure Antarctic krill having Omega-3 EPA and DHA, phospholipids and choline, is clinically proven to support and boost heart health. It helps in lowering the chances of CVD.
OKrill’s Choline and CVD
Choline is a necessary nutrient, required for the holistic health. Many of our body’s processes depends on choline. More critically, it is an essential precursor for acetylcholine, a crucial neurotransmitter. This neurotransmitter helps our muscles, particularly the heart, to operate efficiently.
High homocysteine levels are linked to cardiovascular disease risk factors. They have been shown to damage arteries and other blood vessels, which can eventually result in cardiovascular issues. Choline aids in the transformation of homocysteine into methionine, which may subsequently be safely used by the body or gets eliminated. In this way, consuming choline can assist in regulating homocysteine levels.
OKrill is a rich source of choline, which is necessary for a healthy cardiovascular system.
OKrill and Omega 3 Fatty Acids
OKrill’s Omega-3 fatty acids are amongst the most recognized nutrients that boosts cardiac health. According to a study by Yang Hu et al, which included data from several trials and meta-analyses of numerous studies, supplements of marine omega-3 is linked to a decreased risk of Myocardial Infarction (Heart Attack), Congenital Heart Defects (CHD), Cardiovascular Diseases (CVD) and death from CHD or CVD causes.
OKrill is a supplement enriched with active components including omega 3 fatty acids.
Suggested Reading: Krill Oil & Heart Health
In a study done by Vanu R Ramprasath et al, the findings suggest that krill oil may be more effective than fish oil in boosting n-3 PUFA, lowering the n-6:n-3 PUFA ratio, and enhancing the omega-3 index, which helps in reducing cardiovascular disease (CVD) risk.
Suggested Reading: Krill Oil & Heart Health
Krill Oil, EPA & DHA
Antarctic krill, is a marine crustacean rich in both eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA). The study by Kevin S Maki et al concluded that plasma EPA and DHA concentrations increased significantly more in the krill oil. Four weeks of krill oil supplementation increased plasma EPA and DHA and was well tolerated in the overweight participants.
Krill Oil and Hyperlipidemia
Heart disease and stroke risk can be increased by high levels of LDL (Low-density lipoprotein) cholesterol. HDL (high-density lipoprotein) cholesterol, also known as “good” cholesterol, carries cholesterol from body and transports it to the liver. The liver then eliminates the cholesterol from our body.
Krill oil considerably lowers total cholesterol, LDL, and triglycerides. It significantly raises good cholesterol or HDL levels, making it an excellent treatment for hyperlipidemia. It considerably outperformed fish oil due to lowering levels of glucose, triglycerides, and LDL.
Krill Oil and Severe Hypertriglyceridemia
This is one of the largest Omega-3 study to date, investigating very high triglyceride (TG) levels. It was 40-million-dollar study on a population of 520 people (having very high triglyceride levels in the blood >500mg/dl) with longest study period (26 weeks) across 164 test centers in the US, Canada and Mexico.
The research found that Omega-3 – PL/FFA, a novel krill oil-derived Omega-3 formulation, reduced TG levels. It was safe and well tolerated in patients with severe hypertriglyceridemia. Krill oil group showed 26% reduction in blood triglyceride levels after 12 weeks, versus a 15.1% reduction in the placebo group. Krill oil group also showed a 33.5% reduction in blood triglyceride levels after 26 weeks, versus a 20.8% reduction in other group.
Suggested Reading: Krill Oil & Heart
Krill Oil Can Reduce Cholesterols
Krill oil supplementation can reduce low-density lipoprotein cholesterol and triglycerides. It is clinically proven to increase Omega-3 Index. Krill oil supplementation is found to be effective in lowering plasma concentrations of LDL-C and triglycerides, as well as increasing those of HDL-C.
Suggested Reading:Krill Oil & Heart
Krill Oil and Fasting Triglycerides
Berge et al in 2014 concluded that krill oil significantly reduced fasting triglycerides over a period of 12 weeks. In conjunction with dietary and physical activity modifications, krill oil may substantially reduce the risk of cardiovascular disease mortality and morbidity.
The participants of this study, who used krill oil for 12 weeks, had 10% reduction in their fasting triglyceride levels (a risk factor for cardiovascular disease).
Suggested Reading:Krill Oil & Heart Health
Krill Oil Reduces CVD Risk in Diabetes Patients
Krill oil supplementation helps to reduce cardiovascular risk factors in patients with type 2 diabetes. Jessika M Lobraico et al studied that four weeks of krill oil supplementation improved endothelial function and reduced C peptide levels. The krill oil supplement improved insulin resistance, as calculated in patients with type 2 diabetes. Following 17 weeks of krill oil supplementation, the serum high-density lipoprotein increased to more optimal levels.
Suggested Reading:Krill Oil & Heart Health
Astaxanthin and Cardiac Functioning
In a study by Takao Kato et al, heart failure patients with left ventricular (LV) systolic dysfunction, who took astaxanthin supplements for three months, exhibited reduced oxidative stress, improved cardiac contractility and enhanced exercise tolerance. The link between oxidative stress reduction and increased ventricular contractility shows that astaxanthin supplementation has the therapeutic potential to improve heart function.The findings suggest that krill oil may be more effective than fish oil in boosting n-3 PUFA, lowering the n-6:n-3 PUFA ratio, and enhancing the omega-3 index.
Astaxanthin is an active component of OKrill.
Suggested Reading:Astaxanthin & Heart Health
Scientific Evidence:
1. Bunea R, El Farrah K, Deutsch L. Evaluation of the effects of Neptune Krill Oil on the clinical course of hyperlipidemia. Altern Med Rev. 2004 Dec;9(4):420-8. PMID: 15656713 https://pubmed.ncbi.nlm.nih.gov/15656713/
2. Mozaffarian D, Maki KC, Bays HE, Aguilera F, Gould G, Hegele RA, Moriarty PM, Robinson JG, Shi P, Tur JF, Lapointe JF, Aziz S, Lemieux P; TRILOGY (Study of CaPre in Lowering Very High Triglycerides) investigators. Effectiveness of a Novel ω-3 Krill Oil Agent in Patients With Severe Hypertriglyceridemia: A Randomized Clinical Trial. JAMA Netw Open. 2022 Jan 4;5(1):e2141898. doi: 10.1001/jamanetworkopen.2021.41898. PMID: 34989797; PMCID: PMC8739762
https://jamanetwork.com/journals/jamanetworkopen/fullarticle/2787655
3.Ursoniu S, Sahebkar A, Serban MC, Antal D, Mikhailidis DP, Cicero A, Athyros V, Rizzo M, Rysz J, Banach M; Lipid and Blood Pressure Meta-analysis Collaboration Group. Lipid-modifying effects of krill oil in humans: systematic review and meta-analysis of randomized controlled trials. Nutr Rev. 2017 May 1;75(5):361-373. doi: 10.1093/nutrit/nuw063. PMID: 28371906
https://academic.oup.com/nutritionreviews/article/75/5/361/3078064?login=false
4. Berge K, Musa-Veloso K, Harwood M, Hoem N, Burri L. Krill oil supplementation lowers serum triglycerides without increasing low-density lipoprotein cholesterol in adults with borderline high or high triglyceride levels. Nutr Res. 2014 Feb;34(2):126-33. doi: 10.1016/j.nutres.2013.12.003. Epub 2013 Dec PMID: 24461313.
https://www.sciencedirect.com/science/article/pii/S0271531713002832?via%3Dihub
5. Lobraico JM, DiLello LC, Butler AD, et alEffects of krill oil on endothelial function and other cardiovascular risk factors in participants with type 2 diabetes, a randomized controlled trialBMJ Open Diabetes Research and Care 2015;3:e000107. doi: 10.1136/bmjdrc-2015-000107
6.Kevin C. Maki, Mathew S. Reeves, Mildred Farmer, Mikko Griinari, Kjetil Berge, Hogne Vik, Rachel Hubacher, Tia M. Rains,Krill oil supplementation increases plasma concentrations of eicosapentaenoic and docosahexaenoic acids in overweight and obese men and women,Nutrition Research,Volume 29, Issue 9,2009,Pages 609-615,ISSN 0271-5317,https://doi.org/10.1016/j.nutres.2009.09.004.
https://www.sciencedirect.com/science/article/pii/S0271531709001614
7. Ramprasath VR, Eyal I, Zchut S, Jones PJ. Enhanced increase of omega-3 index in healthy individuals with response to 4-week n-3 fatty acid supplementation from krill oil versus fish oil. Lipids Health Dis. 2013 Dec 5;12:178. doi: 10.1186/1476-511X-12-178. PMID: 24304605; PMCID: PMC4235028
8. Hu Y, Hu FB, Manson JE. Marine Omega-3 Supplementation and Cardiovascular Disease: An Updated Meta-Analysis of 13 Randomized Controlled Trials Involving 127 477 Participants. J Am Heart Assoc. 2019 Oct;8(19):e013543. doi: 10.1161/JAHA.119.013543. Epub 2019 Sep 30. PMID: 31567003; PMCID: PMC6806028.
9.Kato T, Kasai T, Sato A, Ishiwata S, Yatsu S, Matsumoto H, Shitara J, Murata A, Shimizu M, Suda S, Hiki M, Naito R, Daida H. Effects of 3-Month Astaxanthin Supplementation on Cardiac Function in Heart Failure Patients with Left Ventricular Systolic Dysfunction-A Pilot Study. Nutrients. 2020 Jun 26;12(6):1896. doi: 10.3390/nu12061896. PMID: 32604721; PMCID: PMC7353230
https://www.who.int/health-topics/cardiovascular-diseases#tab=tab_1
https://www.ahajournals.org/doi/epub/10.1161/01.CIR.0000038493.65177.94
*OKrill is made from 100% original, pure krill oil, extracted from the Krill found in the pristine waters of Antarctica.
